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Data and Samples
The HUNT diabetes cohort includes phenotypes, inclusionand exclusion criteria, complications and severity related to diabetes in an entire regional population collected since 1984. The HUNT diabetes cohort consists of 6,827 cases with annotations, clinical data, genetic data and laboratory tests, making it one of the largest of its kind.
Data and samples
In the planning of diabetes related trials and investigations, data from HUNT is available for all donors collected from 1984 to 2008 (Table 1). A virtually unlimited recourse of data can be used to test various early hypotheses in the initiationof trials. The biomaterial samples consist of blood, serum, plasma, urine, immortalized cells, and FTA epithelialcells. Diabetes participant information covers in average 2.000 variables including age, weight, blood pressure, and smoking. In addition to the listed biomaterial, DNA was extracted and normalised. The metabochip, which was used for genomics, is a custom genotyping array test from Illumina. It is designed to study rare genetic variants in selected regions. In addition, more than 50 demographic variables where collected during HUNT 1, HUNT 2, and HUNT 3.
More than 100 different laboratory tests have been performedand every donor went through a broad selection of clinical examinations. The donors have also provided additional information on health status and familydisease history covering more than 20 common diseases.
| HUNT 1 | HUNT 2 | HUNT 3 | Total | ||
|---|---|---|---|---|---|
| Year | 1984-1986 | 1995-1997 | 2006-2008 | ||
| Donors with diabetes (*) | 2,666 | 1,972 | 2,189 | 6,827 | |
| Diabetes Type | Classical Type 1 | - | 155 | 152 | 307 |
| Type 2 | 380 | 1,329 | 1,628 | 3,337 | |
| MODY | - | 14 | 19 | 33 | |
| LADA | - | 147 | 92 | 239 | |
| Other/not differentiated | 2,286 | 327 | 298 | 2,911 | |
| Biomaterial | Serum | 380 | 1,972 | 2,189 | 1,541 |
| Plasma | - | 1,972 | 2,189 | 4,161 | |
| Immortalised cells | - | - | 2,189 | 2,189 | |
| Genomics | Diabetes Single SNPs | - | 1,500 | - | 1,500 |
| Diabetes Metabochip (**) | - | 750 | - | 750 |
Table 1. Biological material stored in HUNT biobank relevant for diabetes research. Donors with diabetes are overlapping to some degree between HUNT1, 2, and 3. *: A total of 4,161 donors with disease differentiated diagnosis of T1D, T2D, LADA (Latent Autoimmune Diabetes in Adults), MODY (Maturity Onset Diabetes in the Young). **: In addition, HUNT has equally sized controls group matched by age and sex analysed with the same chip.
The diabetes sub-studies
The HUNT Diabetes cohort consists of 6.827 HUNT donors where several have been enrolled in a number of sub-studies (Figure 1). Diabetes sub-studies started in 1982 and annual followups are planned until 2026. The scientific production so far covers close to 200 publications and 15 completed PhD theses. One of these sub-studies is the DE-PLAN EU project, where prevention using lifestyle, physical activity and nutritional intervention is studied. A total of 5.428 HUNT participants were included in the DE-PLAN project.
Disease sub-study differentiation includes type1 diabetes mellitus (T1D), type 2 diabetes mellitus (T2D), latent autoimmune diabetes in adults (LADA), gestational diabetes mellitus (GDM) and mature onset diabetes of the young (MODY). In addition to the WHO guide on differentiation of diabetes, HUNT also contain Finnish diabetes risk score (FINDRISC) scores for all donors in HUNT 2 and 3. The FINDRISC system is endorsed by the WHO and the International Diabetes Federation (IDF). FINDRISC is a low-level, fast, simple questionnaire that provides an estimate of each individual’s risk of developing diabetes in the next 10 years.
The diabetes sub-studies in HUNT
Figure 1. The diabetes sub-studies in HUNT1 (n=2,666), HUNT2 (n=1,972), and HUNT3 (n=2,189). All sub-studies include severalquestionnaires, clinical measurements, laboratory tests, and planned follow-ups. OGTT: Oral Glucose Tolerance Test.
